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A single dose of either two 4 mg tablets or two 4 mg capsules was administered under fed and fasting conditions in an open label, four period, randomized crossover study in 96 human volunteers, of whom 81 were. Acetaminophen. Hypersensitivity; Concomitant ciprofloxacin or fluvoxamine, or other potent CYP1A2 inhibitors; Effects of Drug AbuseTizanidine is used to relieve the spasms and increased muscle tone caused by multiple sclerosis (MS, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control), stroke, or brain or spinal injury. 3 to 0. What is this medication? TIZANIDINE (tye ZAN i deen) treats muscle spasms. People respond to different foods in various ways. 29 mg equivalent to 2 mg tizanidine base, 4. 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